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Judith Grisel, the author of Never Enough: The Neuroscience and Experience of Addiction, has a PhD in neuroscience…. and from the age of 13 to 22 she was a heavy user of alcohol, marijuana, cocaine, opioids, LSD, barbituates, meth, and every other drug she could lay her hands on (she’s been clean for three decades.) Fascinating throughout.

“Opiate tolerance is mind-boggingly robust. Addicts can administer up to 150 times the dose that would be lethal to naive users, and, even so, just feel ‘right’ but not really high.”